Auricularia auricula georgia7/6/2023 ![]() ![]() The authors explicitly decided to not give any recipes, given that many of the species are widespread, and compound composition-and with it possible toxic effects-might vary across the distribution range, so that a preparation method that sufficiently reduces toxicity in the Caucasus might not necessary be applicable in other areas. Some of the ingredients are toxic in larger quantities, and the participants pointed out that careful preparation was needed. The wide use of leaves for herb pies and lactofermented is of particular interest. Other diversity indices also unequivocally pointed to considerably more diverse family composition of wild collected versus garden plants as the differences between all the tested diversity indices appeared to be highly significant. ![]() The richness of plant families was 65 versus 97 families in garden versus wild plants, respectively, and the difference was highly significant. Taxonomically, the difference between two food plant groups-garden versus wild-was strongly pronounced even at family level. The total number of taxa, mostly identified to species, including their varieties, was 527. The Lancet, 389(10085), 2239-2251.The regional division was based primarily on historic provinces of Georgia, which often coincides with the current administrative borders. Trends in Food Science & Technology, 92, 194-204. Dietary plants, gut microbiota, and obesity: Effects and mechanisms. DADA2: High-resolution sample inference from illumina amplicon data. European Journal of Endocrinology, 172(4), R167-R177. Mechanisms in endocrinology: Gut microbiota in patients with type 2 diabetes mellitus. Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers. These results could offer a full explanation and a potential option for the adjuvant therapy of diabetes with AAPs.ĪKT AMPK Auricularia auricula-judae (Bull.) polysaccharides gut microbiota type 2 diabetes.Ībdulmalek, S. Furthermore, our study firstly determined the specific underlying mechanism that AAPs ameliorates T2D through regulating AKT/AMPK pathways and modifying the gut microbiota. PRACTICAL APPLICATION: The article systematically verified the positive effects of AAPs on insulin resistance, glycolipid metabolism disorder, inflammation, and liver injury, key factors closely related to T2D. Overall, this study confirms that AAPs can improve type 2 diabetes by regulating the AKT and AMPK pathways and modulating intestinal microbiota. Particularly, AAPs intervention mainly affected the amino acid metabolism and glycolipid metabolism pathways. In our study, AAPs elevated gut microbiota diversity and optimized microbial composition and function in T2D mice, characterized by increased Lactobacillus and Bacteroides abundance and decreased Clostridium and Allobaculum abundance. Furthermore, we investigated the association between changes of gut microbiota and AAPs effects using high-throughput sequencing of 16S rDNA for fecal samples. In addition, AAPs improved glycolipid metabolism disorders by activating the AKT and adenosine 5`monophosphate-activated protein kinase (AMPK) signaling pathways in T2D mice. The results indicated that 50 and 100 mg/kg AAPs significantly decreased inflammation, liver injury, and insulin resistance. In this study, we explored the effects and potential mechanism of AAPs on type 2 diabetes (T2D) using a high-fat diet and streptozotocin (STZ) induced C57BL/6J mice. It has been shown the potential of AAPs to improve diabetes as an effective adjuvant, but the underlying mechanism remains unclear. The fruiting body is distinguished by its noticeably ear-like shape and brown colouration it grows upon wood, especially elder. auricula (AAPs) are typically fungal polysaccharides and have a wide range of biological activities. Auricularia auricula-judae, known as the Jews ear, wood ear, jelly ear or by a number of other common names, is a species of edible Auriculariales fungus found worldwide. Auricularia auricula-judae is an edible fungus with high nutritional value due to abundant polysaccharides, and is acknowledged as traditional food and medicine in Asia. ![]()
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